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Summary of Transcript:
• Dr. Dale Bredesen, a world-renowned brain health researcher and best-selling author of The End of Alzheimer’s, advocates for cognitive optimization to prevent or delay the onset of neurological decline.
• Central to this approach is understanding the root cause of neurological decline: an insufficiency between supply and demand in the brain’s plasticity network.
• This insufficiency is primarily driven by systemic inflammation, toxicity, lack of trophic support (e.g. proteins that bind to receptors in the brain), and energetics (e.g., oxygen levels).
• These assaults on the brain can stem from everyday sources such as processed foods, mold, air pollution, and sleep apnea among others.
And unfortunately so many of us are literally giving ourselves cognitive decline or simply sub-optimal cognition because we are not doing the right thing hey everybody welcome to another episode of health theory i am here with dr dale bredesen who is a world-renowned brain health researcher and the best-selling Author of the end of alzheimer’s dale welcome to the show thanks so much tom great to be here so i want to dive into something that is extraordinarily important to me which is cognitive optimization it’s something that i think a lot about and there are few people that i’ve seen take The approach that you take most people have said for ever basically that there is no cure for um cognitive decline and once you’re sort of on the backslide that’s just it there’s not a lot that you can do um you were so bold as to write a book Called the end of alzheimer’s so what is it that you know that everybody else doesn’t yeah and i should say you know that that cognitive optimization now goes very well with prevention of alzheimer’s in the future so what we used to think of as hey you don’t have To worry about this until you’re in your 60s no we should be doing in our teens 20s 30s 40s we’ll get better outcomes we’ll get you know we will get better brain health we’ll get better performance so the the goal of my laboratory over the years was To look at what are the molecular mechanisms that drive the degenerative state people say alzheimer’s is because of free radicals it’s because of metal binding problems it’s because of misfolded proteins it’s because of prions it’s because you know what what have you and the reality is that people don’t understand what it is So that’s what we set out to look at 30 years ago and what we found was really surprising what we found is that at the heart of alzheimer’s is an insufficiency you literally have a plasticity network in your brain that responds and again this is not surprising if you think about What it takes to make a country work or to make your business work you have a supply you have a demand so what happens in alzheimer’s you have a chronic mismatch between the demand and the supply and there are four big things that affect those number one anything that drives ongoing Inflammation and that can be dentition so changes in your oral microbiome changes in your sinus microbiome gut microbiome um systemic inflammation metabolic syndrome uh p gingivalis herpes simplex one on and on and on anything that drives inflammation anything that adds toxicity to your brain and unfortunately as you know we Are all exposed to toxins like never before from the california fires to the you know the air pollution that we live with to the processed foods that we are exposed to you know on and on and on to you know the water supply and on and on So those are two of the big ones the third one is trophic support so this was actually discovered years ago by rita levy montgomery who won the nobel prize for her work she discovered the first one which she called the nerve growth factor these are typically proteins that bind To specific receptors in your brain and essentially say things are good so what happens with alzheimer’s is you have this set of things that are sub-optimal and as i said that can be inflammatory things it could be toxic things can be reduced growth factor and trophic support including nutrients and hormones and Then energetics and that’s a misunderstood one many people here’s a simple example of many you go to sleep at night you drop your oxygenation for many people they don’t realize this is happening sometimes in their 20s 30s 40s now you can check this easily check it with your apple watch Check it you know with a better whatever you like or get out or get a sleep study you should be sitting at 96 to 98 percent oxygen what drops people’s levels so when i started researching you i literally immediately i just i paused my research and went and bought two oximeters one For myself and one for my wife and then i started thinking well wait a second what would cause my oxygen levels to drop would it be um just sleep apnea or are there other things yeah the most common is sleep apnea and by the way that happens more In males more as we get a little older more as we are a little overweight which again a big problem in our country uh in the western world more as we have inflammation so systemic inflammation associated with sleep apnea a lot of people will actually improve their sleep Apnea just as they improve their inflammatory status but there are also other conditions uh there’s one for example something called uars upper airway resistance syndrome where you don’t actually have apnea episodes but you are essentially struggling to get enough air through there while you’re sleeping so it’s a resistance Syndrome and by because of that you’re now repeatedly making a little bit of adrenaline boom so you’re waking up again and again and again so again good to know that you’re sleeping that you’re getting enough rem sleep you’re getting enough slow wave sleep you’re getting enough deep sleep And you’re getting enough overall sleep these are all critical features again these are things that we take for granted and unfortunately so many of us are literally giving ourselves cognitive decline or simply sub-optimal cognition because we are not doing the right thing so i’m gonna i’m gonna put a mile marker For people and as soon as i heard you say it i thought oh my god of course this is the answer that it’s diet it’s lifestyle it’s uh exposure to toxins it’s like a whole bunch of things i’ve heard you say before there’s no silver bullet but there’s potentially silver buckshot that If if we deal with all of these different assaults on the brain that are causing the the um insults the injuries then you’re not going to have the cognitive decline that it isn’t the amyloid plaque to use an analogy um so many people and this is the part that Literally until two days ago when i started researching for this um i hadn’t heard anybody say i i had only ever heard amyloid plaque amyloid plaque emily plaque and if you think of amyloid plaque as the water that’s on the house after a house fire your to blame the water would be to Fundamentally misunderstand the problem and you talk like a functional medicine practitioner so can you walk us through like just the basic things that people encounter on a daily basis you threw out processed food already but things like mold and you talked about air pollution like what are some of the the just Everyday insults people are taking yeah so let me just quickly walk through what this disease actually is because that’s the whole that’s the whole point of this that when you’re stuck back in the idea that the amyloid is causing the id the disease itself it makes no fundamental sense Then you say well wait a minute amyloid turned out to be an antimicrobial peptide so no surprise it is part of your defense so again your brain is deciding are things good and i’m going to grow and maintain synapses or am i under assault from any of these various Things that we’ll talk about and therefore i have to go into protection mode i’m going to pull back and say okay i won’t have quite as many synapses but i’ll survive and that’s what’s happening as we get a little older we begin before you know 20 years before alzheimer’s we begin to downsize Unfortunately let’s get into the mechanism of that really fast so i like that it’s very clear and i know hippocampal density is one of the things you look at to judge whether somebody is having this problem or not so what’s going…
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Summary of Description:
In this episode, Dr. Dale Bredesen discusses the reversibility of cognitive decline and Alzheimer’s disease. He explains simple ways to improve these conditions, avoid them altogether, and enhance mental cognition. He outlines four factors responsible for the decline in optimal cognitive performance and suggests detoxing, reducing toxins, and eating a healthy diet in order to flush out amyloid plaque. He also encourages testing for systemic inflammation and promotes his upcoming book about survivors of Alzheimer’s.
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Understanding Cognitive Decline and Reversing Alzheimer’s Disease with Dr. Dale Bredesen
We all know someone who is dealing with cognitive decline, whether it be a family member or close friend. The notion that cognitive decline is an unavoidable part of aging is one that has been accepted for far too long. Thankfully, this is no longer the case. International expert in neurodegenerative diseases, Dr. Dale Bredesen, recently spoke with Tom about the reversibility of cognitive decline and Alzheimer’s disease.
The Relationship between Cognitive Optimization and Alzheimer’s
Dr. Bredesen discussed the importance of cognitive optimization and the role it plays in preventing Alzheimer’s disease. He explained that cognitive decline can begin as early as your 30s, and that many people don’t recognize it at its onset. He also revealed that the four factors largely responsible for the decline in optimal cognitive performance are toxins, inflammation, nutritional deficiencies, and hormone imbalances.
Dr. Bredesen’s Upcoming Book “The First Survivors of Alzheimer’s”
Dr. Bredesen has just released his latest book, “The First Survivors of Alzheimer’s”, which focuses on the stories of those who have successfully reversed their cognitive decline and Alzheimer’s disease. He also discussed the importance of reducing toxins, and the relationship between leaky gut, inflammation, and cognitive decline. He also warned of the danger of consuming too much Omega-6 fatty acids, and revealed his Keto Flex 12-3 diet.
Testing for Systemic Inflammation
Dr. Bredesen also discussed the importance of testing for systemic inflammation, as this can be an indicator of cognitive decline. He advised to look for signs of inflammation in the blood, and to take steps to reduce inflammation. He also suggested eating a healthy diet, with plenty of protein and healthy fats, and avoiding simple carbohydrates.
Conclusion
Cognitive decline is a serious issue, and one that can have a devastating impact on your life. Thankfully, with the help of experts like Dr. Dale Bredesen, we can now take steps to reverse the effects of cognitive decline and Alzheimer’s disease. By reducing toxins, avoiding inflammation, eating a healthy diet, and taking steps to optimize cognitive performance, we can avoid cognitive decline and maintain our mental health.
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Source Description
This episode is sponsored by Pique Tea. Visit https://piquetea.com/impact and get 5% off your first order.
Are you dealing with mental fog most days, crashing in the afternoons and just blaming it on lack of sleep or stress? Cognitive decline is known to begin as early as your 30s and has become the accepted norm with aging, yet many of us don’t even recognize it at its onset. In this episode, international expert in neurodegenerative diseases, Dr. Dale Bredesen, talks with Tom about the reversibility of cognitive decline and Alzheimer’s disease. While Alzheimer’s disease is well known as a progressive disease impacting seniors, too many people are missing the opportunity to course correct and reverse the effects of cognitive decline leading to Alzheimer’s disease in their younger years. Dr. Bredesen explains simple ways for you to improve these conditions, avoid them altogether, and enhance your mental cognition. He discusses the importance of reducing toxins and exposes four factors that are largely responsible for the decline in optimal cognitive performance.
Pre-order Dr. Bredesen’s Book “The First Survivors of Alzheimer’s” https://www.amazon.com/First-Survivors-Alzheimers-Patients-Recovered/dp/0593192427
SHOW NOTES:
Alzheimer’s | Relationship between cognitive optimization and Alzheimer’s [1:17]
Cognitive Supply & Demand | Factors that affect the brain’s plasticity network [2:38]
Brain Assaults | Dr. Bredesen reveals the kind of assaults causing injury to your brain [6:10]
Amyloid Plaque | Dr. Bredesen explains the role of amyloid plaque in Alzheimer’s [7:20]
Brain Shrinkage | Dr. Bredesen explains the problem with the brain chronically shrinking [9:23]
Alzheimer’s Subtypes | What’s destroying your brain and subtypes of Alzeheimer’s [10:10]
Leaky Gut | The relationship between leaky gut, inflammation and cognitive decline [10:59]
Insulin | Dr. Bredesen explains insulin resistance associated to cognitive decline [11:55]
Alzheimer’s Survivors | Dr. Bredesen’s upcoming book about survivors of Alzheimer’s [15:53]
Enhanced Cognition | Dr. Bredesen on enhancing normal cognition [17:01]
Detox | Ways to get rid of toxins and who benefits from detoxing [18:15]
How to Get Alzheimer’s | Dr. Bredesen discuss ways to give yourself Alzheimer’s [22:28]
Toxins Balanced | Dr. Bredesen explains the dynamic balance of toxins in your body. [24:52]
Inflammation Free | How to flush out amyloid plaque, free of inflammation [31:05]
Optimal Diet | Dr. Bredesen cautions the kind of protein and fats for optimal health [34:09]
Omega-6 Warning | Dr. Bredesen warns of the danger with Omega-6 and healthy ratios [35:12]
Keto-Flex Diet | Dr. Bredesen reveals what the Keto Flex 12-3 diet is [42:34]
Testing Cognition | Dr. Bredesen talks about testing for systemic inflammation [45:52]
QUOTES:
“We all have a some degree of exposure to toxicity by the air we’re breathing, by the water we’re drinking, by the food we’re eating, […] if you’re eating mercury filled seafood, if you’re not eating grass-fed beef, if you have a high carb diet, if you’re eating simple carbs. All of these things are contributing to a lesser than optimal outcome.” [17:30]
“We are all living in a toxic world, that’s the problem […] detoxification is not just for sick people” [21:08]
“Many of us will avoid Alzheimer’s, but we’re still going to have suboptimal cognition.” [24:24]
“You have a dynamic balance. You’re exposed to toxins all the time and you are metabolizing them, inactivating them, excreting them all the time.” [24:52]
FOLLOW Dr. Dale Bredesen:
Website: https://www.apollohealthco.com/dr-bredesen/
LinkedIn:https://www.linkedin.com/in/dale-bredesen-2ab0651/
Facebook: https://www.facebook.com/drdalebredesen/
Risk for Cognitive Decline Test – https://www.apollohealthco.com/cognoscopy/
Prevention and Brain Optimization – https://www.apollohealthco.com/solution/precode/
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