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Summary of Transcript:
The video discusses the role of sirtuins in fat loss and metabolism. Sirtuins are a family of signaling proteins activated by NAD that trigger metabolic and longevity effects. As we age, NAD is used more for DNA protection, reducing the availability of sirtuins. Fasting, intense exercise, caloric restriction, and supplementation can increase NAD levels. Studies on mice and obese humans show that sirtuin activation improves endurance performance, protects against diet-induced obesity, and increases metabolic activity. Obese humans have low levels of certain sirtuins and NAMPT, a required enzyme for NAD formation. Weight loss can increase sirtuin activation, but obese individuals face a double whammy with reduced NAD availability.
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Summary of Description:
Sirtuins are proteins that can positively affect the metabolism and cellular processes, leading to increased longevity. The video discusses the benefits of sirtuins on weight loss and aging. The video references various studies supporting the benefits of sirtuins and promotes a new book release and workout channel. A sponsor, Verso NMN, offers a 30% discount for Black Friday.
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Longevity and Weight Loss at the Same Time – Sirtuins & Aging Genes
Have you heard of sirtuins? These proteins regulate numerous biological pathways in our bodies, including aging and metabolism. In this video, Thomas DeLauer explores the connection between sirtuins, weight loss, and aging genes.
What are Sirtuins?
Sirtuins are a family of proteins crucial in regulating our body’s cellular processes. They are involved in many functions, such as DNA repair, metabolism, and inflammation. Because they are interested in many different pathways, sirtuins are considered key regulators of aging.
Sirtuins and Aging Genes
One of the biggest impacts of sirtuins is on aging genes. Specifically, sirtuins activate genes that promote longevity and protect against age-related diseases. Sirtuins regulate a group of genes called “sirtuins genes,” which promote cellular repair and slow down the process of aging.
Effect of Sirtuins on the Metabolism
Sirtuins also play a role in our metabolism, particularly in how our body handles energy. One of the primary ways they do this is by interacting with insulin. Insulin is a hormone that regulates blood sugar, and sirtuins help to make insulin more effective. When insulin works properly, it can help cells absorb glucose (a type of sugar) from the blood, which helps to maintain stable blood sugar levels.
Sirtuins also regulate another hormone called adiponectin, produced by fat cells. Adiponectin plays an important role in metabolism and helps to reduce inflammation in the body. Sirtuins help increase adiponectin availability, which can improve insulin sensitivity and overall metabolic health.
Sirtuins and Weight Loss
Interestingly, sirtuins have also been shown to impact weight loss. One study found that sirtuins can help to increase the activity of brown fat cells, which are responsible for burning calories and generating body heat. When brown fat cells are activated, they increase energy expenditure and promote weight loss.
Additionally, sirtuins may also help to regulate our hunger hormones. One study found that sirtuins can increase the production of a hormone called PYY, which helps to reduce appetite and promote feelings of fullness.
Takeaways
Sirtuins play a key role in aging, metabolism, and weight loss. By activating genes that promote longevity and regulating insulin and adiponectin, sirtuins can help to improve metabolic health. Additionally, by increasing the activity of brown fat cells and regulating hunger hormones, sirtuins can promote weight loss.
If you’re interested in learning more about sirtuins and how they impact our health, check out the references listed above. By understanding the complex biology of our bodies, we can take steps to optimize our health and longevity. And if you’re interested in supporting this channel, check out Verso NMN and their Black Friday deal!
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Source Description
30% off Verso NMN (Today’s Sponsor) for Black Friday: http://www.ver.so/blackfriday
Longevity and Weight Loss at the Same Time – Sirtuins & Aging Genes
Sirtuins can positively affect Weight Loss and Aging- Here is How!- Thomas DeLauer
This video does contain a paid partnership with a brand that helps to support this channel. Because of brands like this, we can provide the content we do for free.
My new book, Intermittent Fasting Made Easy, will be released on March 22nd, 2022! Be the first to get it by preordering here: https://www.amazon.com/exec/obidos/ASIN/0760373868/
Please check out the new workout channel, Garage Built Life, here: https://www.youtube.com/channel/UCQPQImPsw74KhO0Zy2-leyA/videos
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References
https://www.nature.com/articles/nrm.2017.53
https://pubmed.ncbi.nlm.nih.gov/19046567/
https://academic.oup.com/jcem/article/101/3/1263/2804942
https://academic.oup.com/jcem/article/101/3/1263/2804942
https://www.frontiersin.org/articles/10.3389/fendo.2018.00449/full
https://pubmed.ncbi.nlm.nih.gov/17877786/
Timestamps ⏱
0:00 – Intro
0:53 – What are Sirtuins?
4:35 – Effect of Sirtuins on the Metabolism
10:25 – Recap
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