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Summary of Transcript:
The video is a podcast episode where Peter Attia interviews Dr. Nir Barzilai about longevity and centenarians. They discuss the role of genetics and environment in determining lifespan and healthspan. Barzilai explains that while genetics may not play a significant role in people living to be 70 or 80, it does play a bigger role in those living to be 90 or 100. They also discuss the three hypotheses about why centenarians age gracefully: the environment, a perfect genome, and genes that slow aging. Barzilai describes a study that sequenced the genomes of 44 centenarians looking for genes that cause disease and found that they had fewer disease-causing variants. They also touch on the relationship between low birth weight and epigenetic imprinting, which affects healthspan.
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Summary of Description:
Nir Barzilai, Director of the Institute for Aging Research at the Albert Einstein College of Medicine, discusses insights on lifespan and healthspan through his research on centenarians and the TAME trial, which investigates the concept that the multi-morbidities of aging can be delayed in humans. He shares insights from genetic studies of centenarians and twins, including common gene variants found in centenarians and important pathways for longevity. He also explores metformin as a longevity tool for humans and discusses the impact it can have on exercise for both strength training and cardiovascular training, as well as future research facilitated by data from the TAME trial. Additionally, Barzilai touches on epigenetic clocks and the potential usefulness of NAD precursors as a gero-protective agent.
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The Peter Attia Drive podcast series has released their latest episode featuring Nir Barzilai, Director of the Institute for Aging Research at the Albert Einstein College of Medicine. In the episode, Nir dives into the topic of lifespan and healthspan with insights into his extensive research on centenarians, including their gene variants and longevity pathways. Nir also discusses the TAME trial, Targeting/Taming Aging with Metformin, a multi-center study investigating the concept that the multi-morbidities of aging can be delayed in humans.
The podcast covers a wide range of topics, including metformin as a longevity tool for humans, studies with both positive and negative results, and its impact on exercise for both strength training and cardiovascular training. Nir also touches on epigenetic clocks and his take on NAD precursors as a potential gero-protective agent.
Throughout the episode, Nir provides insights into the connection between morbidities and extended healthspan, and how we can learn from centenarians about extending lifespan while also trying to improve healthspan. He also discusses the contraction of morbidity that comes with improved healthspan and the importance of defining healthspan. Additionally, Nir shares unique perspectives and positive attitudes of centenarians, and the lessons we can take away from them.
The podcast concludes with a discussion on the challenge of studying metformin in animal models and the potential insights into biomarkers of aging provided by data from the TAME trial. Peter Attia urges listeners to join the membership and sign up for the email newsletter for exclusive content from Nir and other experts in the field of longevity.
Listeners interested in maximizing their health, longevity, and critical thinking will enjoy this ultra-deep-dive podcast series. The Peter Attia Drive covers topics such as fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. As a physician focusing on the applied science of longevity, Peter’s practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan while simultaneously improving healthspan.
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Source Description
View episode show notes here: https://bit.ly/36CzHME
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Nir Barzilai, Director of the Institute for Aging Research at the Albert Einstein College of Medicine, is back for his third appearance on The Drive. In this episode, Nir divulges insights into lifespan and healthspan through the lens of his extensive research on centenarians as well as the latest from the TAME trial (Targeting/Taming Aging with Metformin), a multi-center study investigating the concept that the multi-morbidities of aging can be delayed in humans. He discusses common gene variants found in centenarians, important pathways for longevity, and ultimately what we can learn from centenarians about extending lifespan while also trying to improve healthspan. Additionally, Nir goes into depth on metformin as a longevity tool for humans, including studies with positive and negative results. He discusses the impact metformin can have on exercise for both strength training and cardiovascular training, as well as future research facilitated by data from the TAME Trial. He also touches on epigenetic clocks and concludes with his take on the usefulness of NAD precursors as a potential gero-protective agent.
We discuss:
0:00:00 – Intro
0:00:08 – Insights from genetic studies of centenarians and twins
0:11:13 – Genes with protective variants that aid longevity
0:22:23 – The relationship between growth hormone and IGF-1
0:35:37 – Use of growth hormone as a longevity tool
0:44:29 – Longevity genotypes: the role of APOE e2, Lp(a), Klotho, and CETP
0:50:04 – The correlation between high TSH and longevity
0:56:30 – Important pathways for longevity
1:04:38 – Insights from centenarian studies, nature vs. nurture, and more
1:14:56 – The contraction of morbidity that comes with improved healthspan
1:20:56 – Defining healthspan
1:26:14 – Unique perspectives and positive attitudes of centenarians
1:33:32 – Lessons to take away from centenarians
1:38:48 – Metformin overview: history, studies, and potential for gero-protection
1:50:07 – The TAME trial (Targeting Aging with Metformin)
1:59:29 – The challenge of studying metformin in animals models
2:07:27 – How data from the TAME trial could provide insights into biomarkers of aging and facilitate a future study on proteomics
2:14:54 – The search for biomarkers to identify who can benefit from treatment
2:26:29 – The impact of metformin on exercise, and finding the right indication for the use of metformin
2:39:36 – Are NAD precursors geroprotective?
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About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 40 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).
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centenarians,anti-aging,metformin,longevity,centenarians secrets,centenarians advice,metformin for longevity
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