In summary, deregulated nutrient sensing is a hallmark of aging that can significantly impact our health and lifespan. As we age, our body’s ability to sense and react to the nutrients available to our cells declines, leading to adverse consequences, including chronic inflammation, metabolic syndrome, obesity, and diabetes. This is due to the loss of balance between two sets of nutrient-sensing pathways: the anabolic IIS and mTOR pathways and the catabolic AMPK and SIRT pathways.
Balance is critical in maintaining these pathways. While activation of both the IIS and mTOR pathways is necessary for building or repairing muscle tissue and maintaining energy levels, over-activation of these pathways can lead to accelerated aging and shortened lifespans. On the other hand, activation of AMPK and SIRT has slowed the aging process and extended both lifespans and health spans.
To maintain balance and help extend our lifespan, we can improve our diet, eat whole, organic, un-processed, and un-refined foods, and avoid highly processed and refined foods as they can wreak havoc on our nutrient-sensing pathways. We can also activate the AMPK pathway through exercise, such as high-intensity interval training and intermittent fasting.
Supplements like nicotinamide riboside or mono nucleotide can increase NAD+ levels and improve SIRT levels. Metformin is another drug that can upregulate SIRT. While suppressing the mTOR pathway can be done judiciously by taking the drug rapamycin, it is not recommended unless under the guidance of a physician.
The key takeaway is that achieving balance among the nutrient-sensing pathways is crucial to slowing the aging process and extending the lifespan and health span.
*****
*****
Summary of Transcript:
The video discusses the Hallmark of Aging, known as deregulated nutrient sensing, which is the ability of cells to detect and react to the nutrients present in their microcellular environment. As we age, the body’s ability to sense nutrients declines, which can lead to adverse health consequences such as metabolic diseases, obesity, and diabetes. Nutrient sensing consists of four pathways: the IIS and mTOR pathways, which detect high nutrient levels, and the AMPK and SIRT pathways, which detect low nutrient levels. Balancing the activation of these pathways can help extend both lifespans and health spans. The video recommends improving your diet by eating whole, organic, unprocessed, and unrefined foods while also considering the judicious use of supplements, exercise, and drugs to activate or suppress these pathways.
*****
Summary of Description:
The content covers the Hallmark of Aging called nutrient sensing, which involves the body recognizing and utilizing nutrients from food as fuel. The video discusses the pathways involved in nutrient sensing and how they become deregulated with age. The video also explores potential solutions for reversing these changes.
*****
Source Description
DEREGULATED NUTRIENT SENSING & AGING. Today we’ll be covering one of the Hallmarks of Aging, and if you use research into drugs that can extend the human lifespan, one of the most important ones.
Food is essential. We eat food to fuel our bodies to move and repair and build tissues. For our bodies to use food as fuel, they must recognize the nutrients and break them down and utilize them. Good thing our bodies have several mechanisms to make that happen.
This is the latest installment in the series The Hallmarks Of Aging. In today’s video, we will go over nutrient sensing, which pathways are involved, and how those processes change or become deregulated as we age.
And as always, there will be a discussion to go over what, if anything, can be done to reverse those changes. Tune in to learn more about how the body uses food as fuel and how that changes as we age.
