*****
Summary of Transcript:
The video discusses new proposed hallmarks of aging, in addition to the nine already established by Dr. Carlos Otin-Lopez in a 2013 paper. The three new hallmarks suggested by Otin-Lopez and his team are disabled macroautophagy, dysbiosis, and inflammation. Other proposed hallmarks include compromised autophagy, microbiome disturbance, altered mechanical properties, cellular enlargement, and splicing dysregulation. The video provides brief explanations of each of these proposed hallmarks and how they relate to the aging process. The video also mentions an upcoming online course on longevity and invites viewers to sign up for a reduced rate.
*****
Summary of Description:
The video discusses six new hallmarks of aging that have been proposed by scientists, in addition to the nine original hallmarks. The new hallmarks include compromised autophagy, microbiome disturbance, inflammation, altered mechanical properties, cellular enlargement, and splicing dysregulation. The growing understanding of the aging process is becoming more detailed and granular over time, and the video offers an overview of each of the new hallmarks. The video also includes links and discount codes for products and services related to longevity.
*****
Understanding the 15 Hallmarks of Aging
As we age, our bodies undergo a variety of changes. Scientists have been studying these changes for years and have identified nine hallmarks of aging, but now they have proposed six more. In this video, we’ll explore these new hallmarks and what they mean for our understanding of aging.
The Original Hallmarks
Before diving into the new hallmarks, it’s worth briefly reviewing the original nine:
1. Genomic instability: as we age, our DNA becomes less stable, leading to mutations and other changes.
2. Telomere shortening: the telomeres at the end of our chromosomes decrease in length as we age, which can lead to cell death or senescence.
3. Epigenetic alterations: changes in gene expression can occur as we age, leading to altered function in various cells and tissues.
4. Loss of proteostasis: the ability of cells to maintain proper protein folding and degradation declines with age, leading to the accumulation of damaged proteins.
5. Deregulated nutrient sensing: signaling pathways that regulate metabolism become less effective as we age, leading to metabolic dysfunction.
6. Mitochondrial dysfunction: the powerhouses of our cells, mitochondria, can become damaged and less efficient with age.
7. Cellular senescence: some cells stop dividing and instead become senescent, leading to the accumulation of non-dividing cells in tissues.
8. Stem cell exhaustion: the ability of stem cells to regenerate tissues declines with age, leading to loss of function.
9. Altered intercellular communication: the ways that cells communicate with each other can change with age, leading to altered tissue function and inflammation.
Proposed New Hallmarks
Now, let’s explore the six newly proposed hallmarks of aging:
1. Compromised Autophagy: autophagy is the process by which cells break down and recycle old or damaged components. As we age, this process can become less efficient, leading to the accumulation of damaged cellular material.
2. Microbiome Disturbance: the bacteria that live in our gut can change with age, leading to altered immune function and inflammation.
3. Inflammation: chronic inflammation can become more common with age, leading to tissue damage and dysfunction.
4. Altered Mechanical Properties: changes in the physical properties of tissues and cells can occur with age, leading to changes in function.
5. Cellular Enlargement: some cells can become larger as we age, leading to altered function and dysfunction.
6. Splicing Dysregulation: the ways that genes are spliced together to create proteins can become less efficient with age, leading to altered protein synthesis and function.
Running Down the Hallmarks
Understanding these hallmarks is important because each one contributes in some way to the aging process. Some may be more important than others depending on the individual and the particular tissue involved. By understanding these hallmarks, scientists can develop new interventions and therapies to slow or even reverse the aging process.
If you’re interested in diving deeper into the science of aging, consider signing up for an online course like “Introduction to Longevity” or checking out affiliate links for products like Perfect Amino or NutriSense. Together, we can continue to uncover the mysteries of aging and hopefully find ways to live longer, healthier lives.
Don’t forget to follow Lance Hitchings on social media, and with his recommended discount codes, you can try out products like Whoop or Alive By Science yourself.
*****
See Original Source
Source Description
I’ve done 11 videos on the Hallmarks of Aging. Now, scientists have proposed 6 more hallmarks to consider.
That’s 15 in all. In this video, we’ll be briefly exploreing each of the latest 6 hallmarks of aging to be proposed. They include Compromised Autophagy, Microbiome Disturbance, Inflammation, Altered Mechanical Properties, Cellular Enlargement and Splicing Dysregulation.
These 6 new hallmarks mean that our understanding of the aging process is improving and getting more detailed and more granular all the time. Join me as I dive into these new hallmarks.
Here’s the link to sign up for my online course, “Introduction to Longevity”: https://tinyurl.com/54evmby3
•••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••
Social Media:
Facebook: https://www.facebook.com/lancehitchings/
Instagram: https://www.instagram.com/lancehitchings/
Twitter: https://twitter.com/LanceHitchings
•••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••
CHAPTERS & TIMESTAMPS:
Intro: 00:00
The 9 Original Hallmarks of Aging: 01:25
Proposed New Hallmarks: 03:20
Running Down the Hallmarks of Aging: 04:40
•••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••
AFFILIATE LINKS:
Discount code for NutriSense: LANCE25
Links: https://bit.ly/3Wis5Te
Get a free month of Whoop using this link: https://join.whoop.com/35071A
Discount code for Alive By Science: LANCE10
Product Links: https://alivebyscience.com/all-produc…
Discount code for DoNotAge: LANCE
Annual Subscription: https://donotage.org/subscribe/
Products: https://donotage.org/products/
Discount Code for Perfect Amino: HITCH10
PerfectAmino Drink Powder link: http://affiliates.bodyhealth.com/idevaffiliate.php?id=926&url=91
Comments are closed