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Summary of Transcript:
Low-dose rapamycin is being talked about as a potential anti-aging drug due to its ability to improve heart function in aging animals. It has also been shown to improve athletic performance, specifically in cyclists who can cycle faster with a better maximum heart rate on rapamycin. Dr. Alan Green has studied rapamycin as a potential treatment for pre-clinical diseases, such as the cerebral microvascular deterioration in individuals with the apoe 4 gene, which can lead to dementia. Rapamycin has been shown to stop this deterioration and prevent the development of dementia. Additionally, low-dose rapamycin has been shown to be helpful for individuals with a congenital inherited cardiomyopathy, but it is important to start treatment before irreversible damage has occurred. Myoscience Nutrition’s berberine fasting accelerator is another natural supplement that can help support metabolic health and curb cravings, especially at night.
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Summary of Description:
Dr. Alan Green has been using low-dose rapamycin in his clinical practice for years and believes it has potential health benefits for supporting healthspan by slowing down the aging process. Rapamycin is anti-mTOR, which is involved in all age-related diseases, and slowing down mTOR with rapamycin can slow aging. A typical dose is 6 mg, which is less for a smaller healthy person. Rapamycin is good for sports performance because it is good for cardiac performance and helps maintain strength and quality of muscles, but bodybuilders do not benefit from it.
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Understanding the Health Benefits of Low-Dose Rapamycin with Alan Green, MD
As we age, our body undergoes various changes that can lead to health complications, such as chronic inflammation, decline in immune function, and the development of age-related diseases. Dr. Alan Green, MD, has been using low-dose rapamycin in his clinical practice for years to help slow down the aging process and improve overall health. In this article, we explore the potential health benefits of low-dose rapamycin and how it can be used as a tool to support healthspan.
Rapamycin and the Prevention of Dementia
According to Dr. Green, rapamycin has been shown to prevent the deterioration of brain function and the development of dementia. This is because rapamycin is anti-mTOR, and mTOR is involved in all age-related diseases. By slowing down mTOR with rapamycin, we can potentially prevent or delay the onset of age-related cognitive decline.
Pharmaceuticals and End-Stage Disease
Dr. Green emphasizes that pharmaceuticals do not treat end-stage disease. Instead, rapamycin can be used as a tool to support overall health and potentially prevent the development of age-related diseases.
Evolution and Genetic Timebomb of Aging
Dr. Green explains that aging is a programmed genetic timebomb as evolution’s way to promote new gene variations is to eliminate those with old variations with a short lifespan. By slowing down mTOR with rapamycin, we can delay the genetic timebomb of aging and potentially extend our healthspan.
Transplant Patients and Rapamycin Dosage
Dr. Green notes that transplant patients do not benefit from the age/health benefits of rapamycin because the dosing is too high. However, once a week dosing at a lower dosage can give a high level at the beginning of the week to knock out mTOR1 and low enough at the end of the week to not interfere with mTOR2.
Decreasing Innate Immune System Activity
Decreasing the activity of the innate immune system is good for stopping chronic inflammation and age-related diseases. Dr. Green explains that reducing mTOR1 through low-dose rapamycin can reduce innate immune system activity and potentially prevent or slow down the development of chronic inflammation and age-related diseases.
Recommended Dosage of Low-Dose Rapamycin
Dr. Green recommends a typical dose of 6 mg of low-dose rapamycin, although the dosage may be less for smaller, healthy individuals. It’s important to work with a healthcare professional to determine the appropriate dosage for your specific needs.
Effectiveness for Sports Performance and Muscle Strength
Dr. Green notes that rapamycin is good for sports performance because it is good for cardiac performance. It can also help maintain strength and quality of muscles. However, bodybuilders may not benefit from rapamycin as they are already at peak muscle strength.
Final Thoughts
Low-dose rapamycin is a promising tool in the support of overall health and the prevention of age-related diseases. However, it’s important to work with a healthcare professional to determine the appropriate dosage and to monitor for potential side effects. By understanding the potential health benefits of low-dose rapamycin, we can potentially extend our healthspan and improve our overall quality of life.
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Alan Green, MD has been using low-dose rapamycin in his clinical practice for years, we discuss the potential health benefits and ways this can be used as a tool to support healthspan.
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—————————————–Show Notes————————————-
0:00 Intro
5:05 Rapamycin stops this deterioration and the development of dementia.
9:47 Pharmaceuticals do not treat end-stage disease.
11:15 Rapamycin is anti-mTOR. mTOR is involved in all age-related diseases.
19:35 Evolution’s way to promote new gene variations is to eliminate those with old variations with a short lifespan.
24:40 Ageing is a programed genetic timebomb.
30:50 Slowing mTOR with rapamycin slows ageing.
37:40 Transplant patients do not get the age/health benefits because the dosing of rapamycin is too high.
40:18 Once a week dosing gives a high level at the beginning of the week to knock out mTOR1 and it was low enough at the end of the week to not interfere with mTOR2.
41:15 Reducing mTOR1 reduces the activity of the innate immune system.
42:45 Decreasing the innate immune system is good for stopping chronic inflammation and age-related diseases.
48:30 A typical dose is 6 mg. It is less for a smaller healthy person.
50:17 Rapamycin is good for sports performance because it is good for cardiac performance.
54:10 Rapamycin helps maintain strength and quality of muscles.
55:30 Bodybuilders do not benefit from rapamycin.
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