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Summary of Transcript:
Metformin and Berberine are both used as alternative treatments for diabetes and longevity. They have many similarities, including being used as CR mimetics, activating AMPK, and suppressing mTOR. However, there is one big difference between the two. Berberine does not have the side effects of lactic acidosis and vitamin B12 absorption that Metformin can have. Berberine also works differently than Metformin and is known for reducing oxidative stress and inhibiting inflammation. Both have drawbacks, such as the need for a prescription for Metformin and the lack of research on Berberine. A controversial study suggests that exercise and Metformin cancel each other out regarding benefits to fitness, insulin sensitivity, and mitochondrial function.
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Summary of Description:
Metformin and Berberine are both used to treat diabetes and are being considered by the longevity community to extend lifespans potentially. However, a major difference between them could impact the decision of which to take. This video discusses the similarities, drawbacks, and dosing of metformin and Berberine and their significant difference. Studies on the effects of these substances on exercise and aging are also mentioned. Social media and affiliate links are provided in the video description.
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THE RED PILL OR THE BLUE?
Metformin or Berberine? Which Should You Take?
Regarding promoting longevity and treating diabetes, two medications come to mind: Metformin and Berberine. Both have been used for quite some time and are popular among the longevity community. However, one major difference between the two could affect your decision in choosing between them.
In this article, we’ll dive deep into the similarities and differences between Metformin and Berberine, their potential benefits for the aging process, drawbacks, and proper dosing.
What Are Metformin and Berberine?
Metformin is an oral medication that’s been in use for decades, primarily to treat Type 2 Diabetes. It works by reducing the amount of sugar produced by the liver and increasing the body’s insulin sensitivity.
On the other hand, Berberine is a naturally occurring compound found in various medicinal plants that have been used for centuries to treat many ailments, including diabetes. It affects the AMPK pathway, which has different beneficial effects on multiple organs.
How Do Metformin and Berberine Impact the Aging Process?
Both Metformin and Berberine have been shown to have potential benefits in the aging process. They have been found to activate pathways that contribute to longevity, such as NAD+ (nicotinamide adenine dinucleotide) and AMPK (adenosine monophosphate-activated protein kinase).
In one study, it was found that Metformin combined with exercise resulted in a greater increase in muscle mass, as well as improved insulin sensitivity, compared to exercise alone. In another study, it was noted that Berberine had similar effects when combined with training in both humans and rats.
Drawbacks to Metformin and Berberine
As with any medication, there are potential drawbacks to both Metformin and Berberine.
Metformin is known to cause gastrointestinal side effects, such as diarrhea and flatulence, that could be uncomfortable for some people. It also has the potential to cause vitamin B12 deficiency, which could lead to neurologic symptoms if not identified and treated early.
On the other hand, Berberine has a short half-life, which means that it must be taken multiple times throughout the day to maintain proper blood levels. Another drawback is that Berberine is metabolized in the liver so that it could interact with other medications also metabolized there.
Dosing with Metformin and Berberine
Proper dosing for these medications could differ depending on the individual’s age, weight, and medical history. It’s essential to consult with your healthcare provider before starting any medication to ensure it’s safe for you.
For Metformin, the starting dose is usually 500mg once or twice a day, with the dosage being increased gradually over time as tolerated to a maximum amount of 2,000mg daily.
On the other hand, Berberine is typically taken in doses of 500mg to 1,500mg daily, split up into three doses. It’s important to remember that Berberine may interact with other medications, so it’s best to consult a healthcare provider before starting.
Conclusion
In conclusion, Metformin and Berberine are popular choices for treating diabetes and promoting longevity. However, it’s important to consider the potential benefits and drawbacks of each medication and proper dosing before making a decision.
Remember that consulting with a healthcare provider is essential to ensure that any medication is safe for you to take, especially if you’re already taking other medications or have underlying medical conditions. By doing so, you can make an informed decision about which medicine is best suited for you.
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Source Description
THE RED PILL OR THE BLUE? METFORMIN OR BERBERINE? Which should you take? There’s 1 huge difference between them that could rock your decision.
Metformin & Berberine they’ve both been used for treating diabetes. And now they’re both being considered by the longevity community. But there’s one HUGE difference between them that could make all the difference in choosing between them.
In today’s video, I’ll discuss Metformin and Berberine, how much they’re alike, how they both can extend lifespans, the drawbacks for each, and dosing. And I’ll be going into depth about the massive difference between them.
Chapters & Timestamps:
00:00 Intro
01:20 What Are Metformin & Berberine?
03:09 How Do Metformin & Berberine Impact The Aging Process?
07:52 Drawbacks To Metformin & Berberine
12:16 Dosing With Metformin & Berberine
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Link to the previous video on Metformin:
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Links to studies mentioned in this video:
Metformin & Exercise: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351883/
Effects of Berberine & Exercise on Humans: http://ijhs.shmu.ac.ir/index.php/ijhs/article/view/610
Effects of Berberine & Exercise on Rats: https://www.researchgate.net/publication/341607228_The_Aerobic_Training_and_Berberine_Chloride_Intervention_on_Pancreatic_Tissue_Antioxidant_Enzymes_and_Lipid_Peroxidation_in_Type_1_Diabetic_Rats
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SOCIAL MEDIA LINKS:
Facebook: https://www.facebook.com/lancehitchings/
Instagram: https://www.instagram.com/lancehitchings/
Twitter: https://twitter.com/LanceHitchings
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AFFILIATE LINKS:
Discount code for Alive By Science: LANCE10
Product Links: https://alivebyscience.com/all-products-by-delivery-method/
Discount code for DoNotAge: LANCE
Product Links for DoNotAge:
Annual Subscription: https://donotage.org/subscribe/
Products: https://donotage.org/products/
NAD Test Kit: https://donotage.org/products/nad-test-kit/
Discount Code for Perfect Amino: HITCH10
PerfectAmino Drink Powder link: http://affiliates.bodyhealth.com/idevaffiliate.php?id=926&url=91
PerfectAmino Tablets link: http://affiliates.bodyhealth.com/idevaffiliate.php?id=926&url=92
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