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Summary of Transcript:
In this YouTube video, the host Peter Attia talks to Celia Morgan about ketamine and its effects. Morgan has a background in psychology and pharmacology and completed her Ph.D. focused on the effects of ketamine. Ketamine was synthesized in the 1960s as an anesthetic and was initially used because it didn’t cause respiratory depression. One of the perks of using ketamine was that it didn’t have this problem, which is a safety concern with other anesthetic agents. Ketamine is still one of the most widely used anesthetics in the world today, and it’s on the World Health Organization list of essential medicines. Although ketamine has psychoactive effects, it’s still used as an anesthetic because it’s safe physiologically. As for kids, they’re more susceptible to changes in consciousness, and ketamine is used routinely with children. In battlefield medicine, ketamine was the most widely used anesthetic in the Vietnam War.
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Summary of Description:
In this episode of The Peter Attia Drive, host Peter Attia speaks with Celia Morgan, a Professor of Psychopharmacology at the University of Exeter, about the potential therapeutic uses of ketamine in mental healthcare. Morgan discusses the history, neurobiology, and pharmacology of ketamine, its potential promise as a treatment for depression and addiction, and its risks and concerns. She emphasizes the importance of using ketamine in combination with psychotherapy to maximize its benefits and offers advice for those interested in the therapeutic use of ketamine.
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Ketamine, a widely abused drug in the United States, is not only used as a party drug but has shown remarkable and promising effects in treating mental illness such as depression and addiction. However, it differs from other psychedelics such as LSD, MDMA, PCP, and psilocybin, and Celia Morgan, a Professor of Psychopharmacology at the University of Exeter, discusses the potential therapeutic uses of ketamine in mental healthcare in this episode of The Peter Attia Drive podcast.
Celia Morgan delves deep into the neurobiology and pharmacology of ketamine and how it affects users. She explains that using ketamine in combination with psychotherapy maximizes its benefits, and shares details from her clinical trials of ketamine as a treatment for recalcitrant depression and addiction. She also elaborates on the theoretical mechanisms for ketamine’s anti-depressive effects and discusses concerns with overusing ketamine. Additionally, she emphasizes the importance of an intermittent or maintenance dose to treat patients who abuse ketamine.
Moreover, Celia Morgan discusses how ketamine differs from other psychedelics in terms of regulation and abuse, and how it compares with other molecules. She shares her experiences and studies of treating alcohol dependence with ketamine and offers advice for those interested in the therapeutic use of ketamine.
The Peter Attia Drive podcast emphasizes maximizing health, longevity, critical thinking, and a few other things. With over 45 million episodes downloaded, this podcast talks extensively about nutritional interventions, exercise physiology, sleep physiology, mental health, and pharmacology to increase lifespan while simultaneously improving health span. Peter Attia, the host of the podcast, is a physician focusing on the applied science of longevity. Through this podcast, he puts forth his practice of dealing extensively with subjects that can help delay the onset of chronic disease, while simultaneously improving quality of life.
In conclusion, ketamine, when used together with psychotherapy, has shown promising results in treating mental illness, which gives us hope for those who have been suffering from depression and addiction. The Peter Attia Drive podcast, through the voice of Celia Morgan, shares valuable information and advice about how to use ketamine therapeutically to achieve maximum benefits.
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Celia Morgan is a Professor of Psychopharmacology at the University of Exeter who has authored numerous publications on the potential therapeutic uses of ketamine in mental healthcare. In this episode, Celia dives deep into the neurobiology of ketamine, how it affects users, and how it differs from other, more classical psychedelics (LSD, MDMA, PCP, and psilocybin). She explains the potential promise of ketamine as a treatment for recalcitrant depression and addiction, and she details the results from her clinical trials in these areas. She discusses the importance of using ketamine in combination with psychotherapy to maximize its benefits, the potential risks associated with ketamine use, and advice for those interested in the therapeutic use of ketamine.
We discuss:
0:00:00 – Intro
0:00:08 – Celia’s training and interest in ketamine
0:01:58 – The history of ketamine, medical uses, and use as a party drug
0:07:48 – Neurobiology and pharmacology of ketamine
0:19:30 – Ketamine regulation and abuse, and how it compares with psychedelics and other molecules
0:35:38 – Ketamine as a therapeutic for depression [30:45];
0:56:43 – The brain under the influence of ketamine and theoretical mechanisms for its anti-depressive effects
1:07:56 – Risks and concerns with overusing ketamine, and what an intermittent or maintenance dose might look for a patient
1:16:39 – Treating addiction with ketamine: Celia’s studies of alcohol dependance
1:35:49 – Advice for people considering the therapeutic use of ketamine
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About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 45 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).
Learn more: https://peterattiamd.com
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Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user’s own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies.
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