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Summary of Transcript:
• Peter and Rick discussed how fructose metabolism is unique from other nutrients in terms of creating a transient intracellular energy deficit.
• Fructokinase is the first enzyme in fructose metabolism which phosphorylates fructose at the one position without negative feedback.
• The degree of ATP depletion varies with the concentration of fructose, which can be affected by rapid absorption on an empty stomach.
• When fructose enters a cell, it triggers metabolic processes that lead to reduced ATP production, accumulation of fat, and oxidative stress to the mitochondria, leading to a “survival response” for stored energy.
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Summary of Description:
Podcasts
In this episode of The Drive, Peter Attia discusses unique features of fructose metabolism, how it has become potentially hazardous based on our culture’s dietary norms, and strategies for combating the development of metabolic illness. He covers topics such as the decline in metabolic flexibility associated with aging, the impact of fructose metabolism and uric acid on kidney function and blood pressure, and the role of vasopressin in metabolic disease.
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Podcasts
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Exploring the Unique Features of Fructose Metabolism
Fructose metabolism is a complex system that has evolved over time to help human ancestors survive. But today, it can be potentially hazardous due to our culture’s dietary norms. In this episode of The Drive, Rick Johnson, Professor of Nephrology at the University of Colorado, dives into the unique features of fructose metabolism, and how our bodies can generate fructose from glucose.
A Primer on Fructose Metabolism and Uric Acid
Rick explains how circulating glucose and salt levels can activate the conversion of glucose to fructose. He also discusses the decline in metabolic flexibility associated with aging, and how factors such as sugar intake or menopause-associated hormone changes can alter responses to sugar.
Impact of Endogenous Fructose Production on Obesity and Metabolic Syndrome
Rick talks about the impact of endogenous fructose production on obesity and metabolic syndrome. He also provides strategies for combating the development of metabolic illnesses using dietary changes and pharmaceutical therapies.
The Role of Vasopressin in Metabolic Disease
Rick concludes the episode with a discussion of vasopressin, a hormone that facilitates fructose’s effects on weight gain and insulin resistance. He explains how this hormone can play a role in metabolic disease, and how it can be used to combat the negative effects of fructose.
Fructose metabolism is an important system that has evolved over time to help our ancestors survive. But today, it can be potentially hazardous due to our culture’s dietary norms. In this episode of The Drive, Rick Johnson provides a comprehensive overview of fructose metabolism, and explains how it can be used to combat the development of metabolic illnesses. He also discusses the role of vasopressin in metabolic disease, and how it can be used to combat the negative effects of fructose. By understanding the unique features of fructose metabolism, we can make more informed decisions about our diet and lifestyle choices.
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Source Description
View episode show notes here: https://bit.ly/3ugel18
Rick Johnson, Professor of Nephrology at the University of Colorado and a previous guest on The Drive, returns for a follow-up about unique features of fructose metabolism, and how this system that aided the survival of human ancestors has become potentially hazardous based on our culture’s dietary norms. In this episode, Rick explains how the body can generate fructose from glucose and how circulating glucose and salt levels can activate this conversion. He discusses the decline in metabolic flexibility associated with aging, as well as how factors such as sugar intake or menopause-associated hormone changes can alter responses to sugar across a lifetime. In addition, Rick lays out strategies for combating the development of metabolic illness using dietary changes and pharmaceutical therapies, and he discusses the impact of fructose metabolism and uric acid on kidney function and blood pressure. He concludes with a discussion of vasopressin, a hormone that facilitates fructose’s effects on weight gain and insulin resistance.
We discuss:
00:00:00 – Intro
00:00:10 – Unique features of fructose metabolism and why it matters
00:09:00 – A primer on fructose metabolism and uric acid
00:21:04 – Endogenous fructose production, the polyol pathway, and the effect of non-fructose sugars
00:28:20 – Findings from animal studies of glucose and fructose consumption
00:45:06 – What calorie-controlled studies say about the claim that a “calorie is a calorie”
00:56:45 – Implications for aging and disease
01:08:58 – Impact of endogenous fructose production on obesity and metabolic syndrome
01:12:43 – Why vulnerability to the negative effects of sugar increases with age and menopause
01:26:43 – Dietary strategies to reduce the negative impact of fructose
01:43:56 – The role of hypertension in chronic disease and tips for lowering blood pressure
01:54:16 – The impact of fructose and uric acid on kidney function and blood pressure
02:04:50 – The potential role of sodium in hypertension, obesity, and metabolic syndrome
02:11:18 – The role of vasopressin in metabolic disease
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About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 35 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).
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