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Summary of Transcript:
Eileen White is a professor at Rutgers University Cancer Institute in New Jersey with a PhD from SUNY Stony Brook and a postdoc at Cold Spring Harbor Laboratory. Her early work focused on apoptosis, but she stumbled upon etaf AG and that is the focus of the podcast. They discussed the regulation of etaf AG both metabolically and otherwise, and its role in the prevention and treatment of disease. They also discussed the difficulty in understanding the ideal dosing and frequency of fasting as a tool for health.
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Summary of Description:
Podcasts
In this episode of The Peter Attia Drive, Eileen White, Chief Scientific Officer at the Rutgers Cancer Institute, discusses the fundamental role of autophagy in the maintenance of health and prevention of neurodegeneration, cancer, and other diseases. She explains how cancer cells use the autophagy pathway to survive and the importance of autophagy in the brain and liver. Eileen also talks about evidence for cancer treatment by blocking autophagy, finding a molecular signal for autophagy, fasting as a tool for longevity, and other molecules that may induce autophagy.
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Podcasts
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Exploring the Role of Autophagy in Human Health and Disease
In this episode of The Peter Attia Drive, Eileen White, Chief Scientific Officer at the Rutgers Cancer Institute, shares her findings on the role of autophagy in human health and disease. Autophagy, a cellular process that helps cells break down and recycle proteins and other cellular components, is essential for maintaining health and preventing neurodegeneration, cancer, and other diseases.
White discusses the paradoxical finding that autophagy may benefit an existing cancer cell and help it to survive, a discovery which could lead to new possibilities in cancer therapy. We also explore the potential of fasting and molecules that induce autophagy to improve human health.
White explains the critical role of apoptosis, or programmed cell death, in preventing cancer. She also goes into detail about how cancer cells use the autophagy pathway to survive. She further discusses the different stressors that can trigger autophagy, as well as the importance of autophagy in the brain and liver.
White then explains the evidence for cancer treatment by blocking autophagy, as well as the types of cancer that are most autophagy-dependent. We also explore the “autophagy paradox” and the need to find a molecular signal for autophagy.
Finally, White discusses the current knowledge gaps around fasting as a tool for longevity, as well as the use of rapamycin, metformin, and other molecules that may induce autophagy. She explains how to study fasting and exercise as longevity tools, and shares the Nobel Prize for autophagic research.
White’s research provides an important insight into the role of autophagy in human health and disease, and her findings offer new possibilities for cancer therapy. Her work is paving the way for a better understanding of how fasting, exercise, and certain molecules can be used to improve longevity.
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Source Description
Original release date: 6/8/20
In this episode, Eileen White, Chief Scientific Officer at the Rutgers Cancer Institute, describes the fundamental role of autophagy in the maintenance of health and prevention of neurodegeneration, cancer, and other diseases. She also goes into detail about the paradoxical finding that autophagy may benefit an existing cancer cell and help it to survive—a discovery leading to new possibilities in cancer therapy. We also discuss fasting (and molecules that induce autophagy) and the critical need to decode the proper fasting “dose” in order to improve human health.
We discuss:
00:00:00 – Intro
00:03:40 – Eileen’s discovery that a specific oncogene blocks apoptosis
00:10:00 – Defining apoptosis and its role in cancer prevention
00:17:20 – How cancer cells use the autophagy pathway to survive
00:29:15 – Stressors that induce autophagy
00:32:45 – The importance of autophagy in the brain and liver
00:40:00 – The mechanisms that can trigger autophagy to support longevity
00:42:30 – Evidence for cancer treatment by blocking autophagy
00:46:45 – Types of cancer that are most autophagy-dependent
00:52:40 – The autophagy paradox
00:59:15 – Finding a molecular signal for autophagy
01:13:00 – Current knowledge gaps around fasting as a tool for longevity
01:22:15 – Rapamycin, metformin, and other molecules that may induce autophagy
01:32:50 – How to study fasting and exercise as longevity tools
01:36:45 – The Nobel Prize for autophagic research
01:38:25 – Eileen’s future areas of research
01:49:25 – A fasting strategy for Alzheimer’s disease prevention
01:51:30 – Future study of metabolism and autophagy
Show notes page: https://peterattiamd.com/eileenwhite/
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About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 30 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).
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