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Summary of Transcript:
This episode of the Drive Podcast focuses on atherosclerotic cardiovascular disease (ASCVD) and cholesterol. It explains why it is so important to care about ASCVD, the role of cholesterol in ASCVD, why cholesterol should not be referred to as good or bad, and why APO B is an important metric to track when looking at lipids. The episode includes clips from previous episodes and amas and provides commentary to give context. It emphasizes that ASCVD is an inevitable and ubiquitous disease that has a huge impact on human longevity, and that there are tools available to mitigate it. It also explains that while ASCVD is most commonly seen in older people, over 50% of men and one-third of women will have a cardiac event before the age of 65.
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Summary of Description:
This episode of The Drive provides a summary of topics related to cardiovascular disease, including why early prevention is critical, the fallacy of “good” and “bad” cholesterol, the limitations of standard blood panels, and how early and aggressive lowering of apoB could change the landscape of cardiovascular disease prevention. Peter Attia, Allan Sniderman, and Tom Dayspring discuss these topics in detail. Additionally, Peter Attia is a physician focusing on the applied science of longevity, and The Drive is a weekly podcast focusing on maximizing health, longevity, and critical thinking.
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Cardiovascular disease is a major public health problem that affects millions of people around the world. Early diagnosis and intervention are key to preventing the progression of the disease, which is why it is important to understand the underlying causes and risk factors. In this episode of The Drive, Peter Attia, MD, and his guests discuss the importance of understanding cardiovascular disease and the role of lipoproteins and cholesterol in its development. They also discuss the limitations of standard blood panels, the superiority of apoB as a metric for risk prediction, and the potential for early and aggressive lowering of apoB to change the course of cardiovascular disease.
The discussion begins with an overview of atherosclerosis and its causes, as well as the importance of early intervention in preventing its progression. Peter then explains why there is no such thing as “good” or “bad” cholesterol, and how lipoproteins and lipids interact in the body. Allan Sniderman then explains the limitations of standard blood panels, and Tom Dayspring provides an overview of apoB and its role in the development of atherosclerotic cardiovascular disease. Peter then explains how early and aggressive lowering of apoB could change the landscape of cardiovascular disease prevention.
This episode of The Drive provides a comprehensive overview of cardiovascular disease, its causes and risk factors, and the importance of early intervention. It is an invaluable resource for anyone looking to understand this complex topic and to identify potential strategies for prevention. For more information, visit Peter Attia’s website and subscribe to The Drive podcast.
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In this special episode of The Drive, we have pulled together a variety of clips from previous podcasts about cardiovascular disease to help listeners understand this topic more deeply, as well as to identify previous episodes which may be of interest. In this episode, Peter highlights the importance of understanding cardiovascular disease and why early intervention is critical. He also provides a primer on lipoproteins and explains the fallacy of the terms “good cholesterol” and “bad cholesterol.” Allan Sniderman discusses the metrics measured in routine blood work – along with the limitations of those standard panels – before explaining why apoB is a superior metric for determining risk. Additionally, Tom Dayspring explains the casual role of apoB in atherosclerotic cardiovascular disease (ASCVD) and the therapeutic goals for apoB concentration, and Peter explains how early and aggressive lowering of apoB could change the landscape of cardiovascular disease prevention.
We discuss:
-Intro [0:00]
-The importance of understanding atherosclerosis early in life [2:25];
-Defining ASCVD, its causes, and the role of cholesterol [8:00];
-Why early prevention of atherosclerosis is critical [13:45];
-Preventing atherosclerosis—two fatal flaws with the “10-Year Risk” approach [16:00];
-Intro to lipids and lipoproteins: why there is no “bad” or “good” cholesterol [23:00];
-Limitations of standard blood panels [35:45];
-How Mendelian randomization is bolstering the case for apoB as the superior metric for risk prediction [39:30];
-Therapeutic goals for apoB concentration [58:15];
-How early and aggressive lowering of apoB could change the course of ASCVD [1:10:45]; and
-More.
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About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 45 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).
Learn more: https://peterattiamd.com
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Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user’s own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies.
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