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Summary of Transcript:
• Dr. David Pearl Mudder discussed with Tom Bilyeu uric acid being a predictor of hypertension, insulin resistance, and elevated blood sugar, leading to diabetes, inflammation, and oxidative stress.
• Uric acid was once seen as just a factor in gout but is now known to be important for our metabolic health and has been the focus of new research.
• It is understood that metabolic disturbances lead to inflammation which can cause diseases such as Alzheimer’s, heart disease, diabetes, obesity, and cancer.
• Fructose is a primary culprit in metabolic disturbances as it can cause high uric acid levels, damaging cells and tissues due to gluconeogenesis and insulin resistance.
• High salt levels can lead to fructose production through aldosterone reductase, which signals the body for famine or water restriction. Fructose is primarily found in fruit.
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Summary of Description:
Ombre Lab sponsors this episode of Health Theory. Get $30 off your Gut Health testing kit and probiotics at: https://tryombre.com/Impact.
In this episode of Health Theory, Dr. David Perlmutter discusses the latest research on uric acid and its role in metabolism, cardiovascular health, Alzheimer’s, and dementia. He explains the relationship between uric acid, insulin, and fructose, why it doesn’t mean all fruits are rotten for you, and how our modern problem with uric acid results from reconnecting between evolution and the environment. He also advises lowering uric acid levels and outlines the ideal diet and lifestyle for optimal health.
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Fructose is a primary culprit in metabolic disturbances, as it can cause high uric acid levels and damage cells and tissues. This is because fructose is metabolized differently than other sugars, such as glucose. Fructose is primarily metabolized by the liver, which promotes fat synthesis and bypasses the rate-limiting step of glycolysis. This leads to gluconeogenesis and insulin resistance, which can harm our health.
The human body needs fructose to function correctly, but too much can be dangerous. Overeating fructose can increase uric acid levels, damaging cells and tissues. High uric acid levels are associated with several health problems, including gout, kidney stones, hypertension, and heart disease.
In addition to its effects on uric acid levels, fructose also affects our metabolism in other ways. It increases triglycerides in the blood and decreases HDL cholesterol (the “good” cholesterol). It also increases the production of advanced glycation end products (AGEs), which are compounds that form when sugar molecules attach themselves to proteins or fats in our bodies. AGEs are thought to contribute to inflammation and oxidative stress, which are linked to various chronic diseases such as diabetes and cardiovascular disease.
Overeating fructose can lead to weight gain due to its ability to promote fat storage in the liver. It’s essential for people who consume large amounts of fructose to be aware of its potential risks. It’s also necessary for people with diabetes or pre-diabetes to monitor their fructose intake carefully because it can affect their blood sugar levels more quickly than other sugars like glucose or sucrose.
Overall, it’s essential for people who consume large amounts of fructose regularly to be aware of its potential risks so they can make informed decisions about their diet and lifestyle choices. Eating a balanced diet with plenty of fruits and vegetables is always recommended for optimal health, but limiting your intake of added sugars like high-fructose corn syrup may help reduce your risk for metabolic disturbances caused by excessive consumption of this sweetener.
Sources:
- https://www.ncbi.nlm.nih.gov/books/NBK576428/
- https://www.pfizer.com/news/articles/sweet_science_how_insights_into_fructose_metabolism_are_helping_to_fight_liver_disease
- https://en.wikipedia.org/wiki/Fructolysis
When people hear about uric acid, it’s almost always in the context of it being a causal factor for gout.
But if more people knew the full extent of how it affects our metabolism, cardiovascular health, and risk for Alzheimer’s and dementia, we might pay more attention to it.
In this episode of Health Theory, Dr. David Perlmutter returns with the latest research on how uric acid is about much more than gout.
He explains the relationship between uric acid, insulin, and fructose, why it doesn’t mean that all fruits are rotten for you, and how our modern problem with uric acid results from reconnecting between evolution and the environment.
If you want to dive deeper into the latest knowledge bomb from Dr. Perlmutter, you’ll want to check out his new book, Drop Acid: The Surprising New Science of Uric Acid – The Key to Losing Weight, Controlling Blood Sugar and Achieving Extraordinary Health
Click here to pre-order: https://amzn.to/3HQykY5
SHOW NOTES:
00:00 | Introduction
00:43 | Uric Acid and Metabolism
06:42 | The Problem With Fructose
12:22 | What Does Uric Acid Do?
23:58 | Eat to Lower Uric Acid
33:43 | The Cause of Type 2 Diabetes
41:48 | The Ideal Diet & Lifestyle
QUOTES:
“Many roads lead to the Rome of inflammation and set the stage for things like Alzheimer’s and coronary artery disease. And because of that, it’s why monotherapy or a one-drug approach to Alzheimer’s, for example, is beyond myopic. It’s never going to work.” [03:02]
“Our metabolic health globally is in a terrible place. A third of American adults and 10% of kids aged 12 to 18 have hypertension. That’s crazy. 50% of adult Americans will be obese by the year 2030. Not just overweight, but obese.” [04:16]
“Elevation of uric acid is associated with an 80% increased risk of dementia, a 55% increase risk of Alzheimer’s specifically, and a 165% increased risk of vascular dementia.” [13:53]
“What would be the upside of having uric acid create insulin resistance and therefore cause blood sugar to go up? Why? Because when you’re starving, it’ll help power your brain.” [16:50]
“We’re seeing metabolic derangements that underlie these diseases that represent a disconnect between evolution and environment.” [22:06]
“If it has a barcode, and it’s in the grocery store, it has added sweetener – 70% do. And by and large that comes from high fructose, there’s the villain corn syrup that we subsidize to $500 billion a year.” [25:01]
“Uric acid levels are climbing in lockstep with fructose consumption. In the 1920s, Americans’ average uric acid level was about 3.5 – now six.” [46:50]
Follow Dr. David Perlmutter:
Website: https://www.drperlmutter.com
Twitter: https://bit.ly/3GRK37j
Facebook: https://bit.ly/3Bkb8yZ
Instagram: https://bit.ly/3swlmYY
Order Dr. Perlmutter’s new book, Drop Acid: https://amzn.to/3HQykY5
*****
Source Description
Ombre Lab sponsors this episode. To get $30 off your Gut Health testing kit and probiotics — go to: https://tryombre.com/Impact.
When people hear about uric acid, it’s almost always in the context of it being a causal factor for gout.
But if more people knew the full extent of how it affects our metabolism, cardiovascular health, and risk for Alzheimer’s and dementia, we might pay more attention to it.
In this episode of Health Theory, Dr. David Perlmutter returns with the latest research on how uric acid is about much more than gout.
He explains the relationship between uric acid, insulin, and fructose, why it doesn’t mean that all fruits are rotten for you, and how our modern problem with uric acid is acting results in reconnecting between evolution and the environment.
If you want to dive deeper into the latest knowledge bomb from Dr. Perlmutter, you’ll want to check out his new book, Drop Acid: The Surprising New Science of Uric Acid – The Key to Losing Weight, Controlling Blood Sugar and Achieving Extraordinary Health
Click here to pre-order: https://amzn.to/3HQykY5
SHOW NOTES:
00:00 | Introduction
00:43 | Uric Acid and Metabolism
06:42 | The Problem With Fructose
12:22 | What Does Uric Acid Do?
23:58 | Eat to Lower Uric Acid
33:43 | The Cause of Type 2 Diabetes
41:48 | The Ideal Diet & Lifestyle
QUOTES:
“Many roads lead to the Rome of inflammation and set the stage for things like Alzheimer’s and coronary artery disease. And because of that, it’s why monotherapy or a one-drug approach to Alzheimer’s, for example, is beyond myopic. It’s never going to work.” [03:02]
“Our metabolic health globally is in a terrible place. A third of American adults and 10% of kids aged 12 to 18 have hypertension. That’s crazy. 50% of adult Americans will be obese by the year 2030. Not just overweight, but obese.” [04:16]
“Elevation of uric acid is associated with an 80% increased risk of dementia, a 55% increase risk of Alzheimer’s specifically, and a 165% increased risk of vascular dementia.” [13:53]
“What would be the upside of having uric acid create insulin resistance and therefore cause blood sugar to go up? Why? Because when you’re starving, it’ll help power your brain.” [16:50]
“We’re seeing these metabolic derangements that underlie these diseases that represent a disconnect between evolution and environment.” [22:06]
“If it has a barcode, and it’s in the grocery store, it has added sweetener – 70% do. And by and large that comes from high fructose, there’s the villain corn syrup that we subsidize to $500 billion a year.” [25:01]
“Uric acid levels are climbing in lockstep with fructose consumption. In the 1920s, Americans’ average uric acid level was about 3.5 – now six.” [46:50]
Follow Dr. David Perlmutter:
Website: https://www.drperlmutter.com
Twitter: https://bit.ly/3GRK37j
Facebook: https://bit.ly/3Bkb8yZ
Instagram: https://bit.ly/3swlmYY
Order Dr. Perlmutter’s new book, Drop Acid: https://amzn.to/3HQykY5
